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No particular dose adjustment advisable when tofacitinib coadministered with powerful CYP2C19 inhibitors; minimize tofacitinib dose if coadministered with both moderate CYP3A4 and strong CYP2C19 inhibitors .modafinil will enhance the stage or outcome of rabeprazole by impacting hepatic enzyme CYP2C19 metabolism. Minimal/Importance Unfamiliar. Net e